Prevalence and Outcomes of Endovascular Infrapopliteal Interventions for Intermittent Claudication

Academic Article


  • Background: Although endovascular peripheral vascular interventions (PVI) are typically limited to vessels above the knee in intermittent claudication (IC), some patients have concomitant or isolated infrapopliteal disease with IC. The benefits and risks of undergoing tibial intervention remain unclear in IC patients. The purpose of this study is to evaluate the prevalence and outcomes of infrapopliteal PVI for IC. Methods: The Vascular Quality Initiative was queried for PVI procedures performed for IC between 2003 and 2018. Patients were divided into 3 groups: isolated femoropopliteal (FP), isolated infrapopliteal (IP), and combined above and below knee interventions (COM). Multivariable logistic regression models identified predictors of minor and major amputation, as well as freedom from reintervention. Kaplan-Meier plots estimate amputation-free survival. Results: We identified 34,944 PVI procedures for IC. There were 31,110 (89.0%) FP interventions, 1,045 (3.0%) IP interventions, and 2,789 (8.0%) COM interventions. Kaplan-Meier plots of amputation-free survival revealed that patients with any IP intervention had significantly higher rates of both minor and major amputation (log rank <0.001). Freedom from reintervention at 1-year was 89.2% for the FP group, 91.3% for the IP group, and 85.3% for the COM group (P < 0.0001). In multivariable analysis, factors associated with an increased risk of major amputation included isolated IP intervention (OR 6.47, 95% CI, 6.45–6.49; P < 0.0001), COM interventions (OR 2.32, 95% CI, 2.31–2.33; P < 0.0001), dialysis dependence (OR 3.34, 95% CI, 3.33–3.35; P < 0.0001), CHF (OR 1.86, 95% CI, 1.85–1.86; P = 0.021) and, nonwhite race (OR 1.64, 95% CI, 1.63–1.64; P = 0.013). Conclusions: PVI in the infrapopliteal vessels for IC is associated with higher amputation rates. This observation may suggest the need for more careful patient selection when performing PVI in patients with IC where disease extends into the infrapopliteal level.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 6312854
  • Author List

  • Mullins CH; Novak Z; Axley JC; Sutzko DC; Spangler EL; Pearce BJ; Patterson MA; Passman MA; Haverstrock BD; Siracuse JJ
  • Start Page

  • 79
  • End Page

  • 86
  • Volume

  • 70