Application of the †5-2-1' screening criteria in advanced Parkinson's disease: Interim analysis of DUOGLOBE

Academic Article

Abstract

  • Aim: A Delphi expert consensus panel proposed that fulfilling ≥1 of the †5-2-1 criteria' (≥five-times daily oral levodopa use, ≥two daily hours with †Off' symptoms or ≥one daily hour with troublesome dyskinesia) suggests advanced Parkinson's disease (PD). Patients & methods: DUOdopa/Duopa in Patients with Advanced PD-a GLobal OBservational Study Evaluating Long-Term Effectiveness (DUOGLOBE)-is a single-arm, postmarketing, observational, long-term effectiveness study of levodopa-carbidopa intestinal gel (LCIG) for advanced PD. Results: This 6-month interim analysis (n = 139) affirms that most (98%) enrolled patients fulfill ≥1 of the 5-2-1 criteria. These patients responded favorably to LCIG treatment. Safety was consistent with other LCIG studies. Conclusion: In advanced PD patients, the 5-2-1 criteria generally aligns with clinician assessment.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 25209412
  • Author List

  • Aldred J; Anca-Herschkovitsch M; Antonini A; Bajenaru O; Bergmann L; Bourgeois P; Cubo E; Davis TL; Iansek R; Kovács N
  • Start Page

  • 309
  • End Page

  • 323
  • Volume

  • 10
  • Issue

  • 5