Cirrhotomimetic hepatocellular carcinoma: experience of a single institution and review of the literature.

Academic Article


  • Cirrhotomimetic hepatocellular carcinoma is a recognized pattern exhibiting cirrhosis-like growth and a reputation for evading pretransplant detection. Five cases encountered from our institution were retrospectively reviewed. Clinicopathologic and literature reviews were performed. All five patients were male, aged 50-66. Diffuse, innumerable nodules were seen grossly, exhibiting predominantly well-to-moderate differentiation with pseudoglandular and trabecular patterns microscopically. By immunohistochemistry, the tumor was diffusely positive for Glypican-3, showed sinusoidal capillarization by CD34 and slightly increased MIB-1 proliferation index. At up to 3.25 years of follow-up, our cohort of cirrhotomimetic hepatocellular carcinoma had no recurrence in 60% (3/5), solitary recurrence in 20% (1/5) and one patient had died of disease in 20% (1/5). Literature review suggests that these tumors recurred at a frequency of 50% (19 of 38 patients).
  • Published In

  • Hepatic Oncology  Journal
  • Keywords

  • cirrhotic like, cirrhotomimetic, cirrhotomimetic hepatocellular carcinoma, diffuse type hepatocellular carcinoma, hepatocellular carcinoma
  • Digital Object Identifier (doi)

    Author List

  • Xiong M-J; Patel CR; Manne U; Al Diffalha S
  • Start Page

  • HEP28
  • Volume

  • 8
  • Issue

  • 1