Hemodynamically significant patent ductus arteriosus and the development of bronchopulmonary dysplasia

Academic Article


  • Patent ductus arteriosus (PDA) is prevalent in premature newborns and has been linked to the development of bronchopulmonary dysplasia (BPD), a serious pulmonary complication of premature birth. Although a causal relationship has not been proven, the link is greatest among infants born at lower gestational age who are treated with mechanical ventilation in the presence of a large ductal shunt. Despite strong association in epidemiological studies, treatment of a patent ductus arteriosus has not been shown to prevent BPD, and some therapies may increase the risk of BPD. We describe preclinical and clinical data demonstrating the association of a PDA with BPD, highlight the effects of surgical and pharmacological treatment, and explore the implications of recent clinical trials for the management of PDA in the premature newborn.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Willis KA; Weems MF
  • Start Page

  • 27
  • End Page

  • 32
  • Volume

  • 14
  • Issue

  • 1