Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation.

Academic Article


  • GALT contains Tcs cells which protect IgA responses under conditions of oral tolerance. Oral immunization of erythrocyte antigen induces antigen-specific Tcs cells in Peyer's patches which predominantly support IgA responses with minor IgM and IgG responses upon adoptive transfer to tolerized mice. On the other hand, systemically-primed mice possess Tcs cells which convert oral tolerance to only IgM and IgG responses. In general, effector Tcs cells which abrogate antigen-specific oral tolerance are Lyt-1+, Lyt-2-, L3T4-, I-J+ and V. villosa-adherent. Interestingly, these Tcs cells express T3 molecules which suggest the expression of a TCR which may account for their antigen specificity.
  • Digital Object Identifier (doi)

    Author List

  • Fujihashi K; Kiyono H; Beagley KW; Eldridge JH; McGhee JR
  • Start Page

  • 649
  • End Page

  • 653
  • Volume

  • 237