Regulatory functions for murine intraepithelial lymphocytes in mucosal responses

Academic Article


  • Our studies have given direct evidence that CD3+, CD4-, CD8+ T cells in the IELs can be separated into at least two subsets that produce IFN-γ and/or IL-5 and may exhibit Th1- and Th2-type functions in the epithelium and in the underlying lamina propria region. Further, it was also shown that TCR1+ T cells in IELs are capable of producing IFN-γ and/or IL-5. In addition to production of these cytokines, IELs derived from mice orally primed with TD antigen contain a subset of T cells which posses antigen-specific immunoregulatory function. CD3+; CD4-, CD8+ T cells isolated from IEL of TD antigen-primed mice abrogated systemic unresponsiveness to secondary-type responses including those of the IgA isotype upon adoptive transfer to mice with OT. Our studies further suggested that these CD3+, CD4-, CD8+ IELs use the γ-δ form of TCR (TCR1) for their immuno-regulatory function. © 1991 Humana Press Inc.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Kiyono H; Fujihashi K; Taguchi T; Aicher WK; McGhee JR
  • Start Page

  • 324
  • End Page

  • 330
  • Volume

  • 10
  • Issue

  • 3-4