Mucosal vaccination and immune responses in the elderly

Academic Article


  • To develop a mucosal vaccine strategy for the elderly, we have compared mucosal and systemic immune responses between aged (12-14 months) and young adult (8-12 weeks) mice. Both aged and young mice were immunized weekly with three oral doses of 1 mg of ovalbumin (OVA) and 10 μg of cholera toxin as adjuvant. Although elevated levels of OVA-specific systemic IgG and mucosal IgA Ab responses were seen in young mice, aged mice showed impaired antigen- specific mucosal and systemic immune responses. These results suggest that mucosal immunity is down regulated in aged mice. (C) 2000 Elsevier Science Ltd.
  • Published In

  • Vaccine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Fujihashi K; Koga T; McGhee JR
  • Start Page

  • 1675
  • End Page

  • 1680
  • Volume

  • 18
  • Issue

  • 16