Fe-Al-bearing bridgmanite may be the dominant host for ferric iron in Earth's lower mantle. Here we report the synthesis of (Mg0.5Fe3+0.5)(Al0.5Si0.5)O3 bridgmanite (FA50) with the highest Fe3+-Al3+ coupled substitution known to date. X-ray diffraction measurements showed that at ambient conditions, the FA50 adopted the LiNbO3 structure. Upon compression at room temperature to 18 GPa, it transformed back into the bridgmanite structure, which remained stable up to 102 GPa and 2,600 K. Fitting Birch-Murnaghan equation of state of FA50 bridgmanite yields V0 = 172.1(4) Å3, K0 = 229(4) GPa with K0′ = 4(fixed). The calculated bulk sound velocity of the FA50 bridgmanite is ~7.7% lower than MgSiO3 bridgmanite, mainly because the presence of ferric iron increases the unit-cell mass by 15.5%. This difference likely represents the upper limit of sound velocity anomaly introduced by Fe3+-Al3+ substitution. X-ray emission and synchrotron Mössbauer spectroscopy measurements showed that after laser annealing, ~6% of Fe3+ cations exchanged with Al3+ and underwent the high- to low-spin transition at 59 GPa. The low-spin proportion of Fe3+ increased gradually with pressure and reached 17–31% at 80 GPa. Since the cation exchange and spin transition in this Fe3+-Al3+-enriched bridgmanite do not cause resolvable unit-cell volume reduction, and the increase of low-spin Fe3+ fraction with pressure occurs gradually, the spin transition would not produce a distinct seismic signature in the lower mantle. However, it may influence iron partitioning and isotopic fractionation, thus introducing chemical heterogeneity in the lower mantle.