Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans

Academic Article

Abstract

  • In a phase I HIV vaccine trial, Basu et al. show the robust response of HIV Env gp120-specific peripheral blood plasmablasts immediately after vaccination, dominated by VH1 gene usage and V3 region-targeting Abs. They also define persistent linkage of these Env-reactive lineages to the bone marrow CD138+ LLPC compartment.
  • Digital Object Identifier (doi)

    Author List

  • Basu M; Piepenbrink MS; Francois C; Roche F; Zheng B; Spencer DA; Hessell AJ; Fucile CF; Rosenberg AF; Bunce CA
  • Volume

  • 1
  • Issue

  • 2