Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

Academic Article


  • Tan et al. present the cryo-EM structures of essential wild-type and mutant mycobacterial arabinofuranosyltransferase D (AftD), revealing the putative active site geometry and carbohydrate-binding modules. Acyl carrier protein (ACP) was tightly associated with AftD. Impairing ACP binding blocks AftD's active site, suggesting that ACP regulates enzyme function.
  • Published In

  • Molecular Cell  Journal
  • Digital Object Identifier (doi)

    Author List

  • Tan YZ; Zhang L; Rodrigues J; Zheng RB; Giacometti SI; Ros├írio AL; Kloss B; Dandey VP; Wei H; Brunton R
  • Start Page

  • 683
  • End Page

  • 699.e11
  • Volume

  • 78
  • Issue

  • 4