Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

Academic Article

Abstract

  • We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.
  • Published In

  • Oncogene  Journal
  • Digital Object Identifier (doi)

    Author List

  • Stein GS; Lian JB; Van Wijnen AJ; Stein JL; Montecino M; Javed A; Zaidi SK; Young DW; Choi JY; Pockwinse SM
  • Start Page

  • 4315
  • End Page

  • 4329
  • Volume

  • 23
  • Issue

  • 24