Intranuclear trafficking: Organization and assembly of regulatory machinery for combinatorial biological control

Academic Article

Abstract

  • The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Zaidi SK; Young DW; Choi JY; Pratap J; Javed A; Montecino M; Stein JL; Lian JB; Van Wijnen AJ; Stein GS
  • Start Page

  • 43363
  • End Page

  • 43366
  • Volume

  • 279
  • Issue

  • 42