Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

Academic Article

Abstract

  • Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 21567628
  • Author List

  • Stein GS; Zaidi SK; Stein JL; Lian JB; Van Wijnen AJ; Montecino M; Young DW; Javed A; Pratap J; Choi JY
  • Start Page

  • 1
  • End Page

  • 6
  • Volume

  • 87
  • Issue

  • 1