Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines

Academic Article


  • A resin-capture and release strategy for making combinatorial 2,6,9-trisubstituted purine libraries is demonstrated by capturing N9-derivatized purines at the C6 position with a thio-modified polymer. The C2 fluoro group is subsequently substituted with primary and secondary amines followed by thioether oxidation and release by C6 substitution with amines and anilines. This approach complements a previously reported strategy where a 6-phenylsulfenylpurine scaffold was captured at the C2 position with a resin-bound amine.3.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Ding S; Gray NS; Ding Q; Wu X; Schultz PG
  • Start Page

  • 183
  • End Page

  • 186
  • Volume

  • 4
  • Issue

  • 2