© 2020, © Operational Research Society 2020. This issue is the second in the series to explore the intersection of health informatics, healthcare quality and safety, and healthcare simulation. The uses of all three domains to advance healthcare operations has been diverse and intentional across a variety of domestic and international organisations. This issue focuses primarily on studies that use throughput modelling and system modelling. Findings from this special collection of papers demonstrate the value of modelling techniques and their role in predicting and enhancing healthcare operations.