Tissue engineering of small-diameter vascular grafts



  • This chapter describes the current approaches toward small-diameter tissue-engineered vascular grafts. The outstanding problem of failure for grafts smaller than 4 mm diameter remains a challenge and requires a multidisciplinary approach. The perspectives of tissue engineering, surface modification, bioengineering, and emerging technology are discussed. The unifying themes are to mimic the native extracellular matrix, provide a favorable surface for cell proliferation, and develop a functional and confluent blood-contact surface. Continued efforts to produce a demonstrably functional small-diameter vascular graft are desperately needed.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9780081026809
  • Start Page

  • 79
  • End Page

  • 100