Left ventricular assist device-induced reverse ventricular remodeling

Academic Article

Abstract

  • Left ventricular assist devices provide chronic pressure and volume unloading of the dilated left ventricle in patients with end-stage heart failure. This is associated with reverse structural remodeling (normalization of the passive pressure-volume relationship), reverse molecular remodeling (increased expression of several genes involved in calcium metabolism that are down-regulated in heart failure), improved baseline contractility, and improved contractile response to increased heart rate and to beta-agonist stimulation. These findings indicate the profound degree of recovery of myocardial properties in hearts previously considered to have invincible end- stage heart failure. Copyright (C) 2000 by W.B. Saunders Company.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Burkhoff D; Holmes JW; Madigan J; Barbone A; Oz MC
  • Start Page

  • 19
  • End Page

  • 26
  • Volume

  • 43
  • Issue

  • 1