Weight regain and health-related quality of life in postmenopausal women

Academic Article


  • Weight loss improves health-related quality of life (HRQoL). However, regain after loss is common; little is known about the impact of weight regain on HRQoL in postmenopausal women. Woman on the Move through Activity and Nutrition (WOMAN) is a randomized lifestyle intervention trial of diet, physical activity, and weight loss in 508 postmenopausal women aged 52-62 years. This analysis focused on the women who lost ≥5 lb during the initial phase of the study, baseline to 6 months (n = 248). This cohort was divided into three groups based on subsequent weight change between 6 and 18 months: weight loss (WL; ≥5 lb loss), weight stable (WS; <±5 lb change), and weight regain (WR; ≥5 lb gain). HRQoL was measured at baseline, 6, and 18 months using the Short Form-36. Of the 248 women studied, 51 (21%) continued to lose weight after initial weight loss, while 127 (51%) maintained a stable weight, and 70 (28%) regained weight. Between baseline and 6 months, women in WR group had decreased mental health and social-functioning scores, while the WL and WS groups improved in these subscales. Between baseline and 18 months, energy improved most significantly in those with continued weight loss (P = 0.0003). Weight loss was correlated with a small to moderate improvement in perceived general health and energy, which was reversed by weight gain. Further study is needed to investigate the impact of a decline in mental health and social functioning on future weight regain. © 2008 The Obesity Society.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Yankura DJ; Conroy MB; Hess R; Pettee KK; Kuller LH; Kriska AM
  • Start Page

  • 2259
  • End Page

  • 2265
  • Volume

  • 16
  • Issue

  • 10