US-guided percutaneous microwave coagulation of small breast cancers: A clinical study

Academic Article

Abstract

  • Purpose: To determine the feasibility of percutaneous microwave coagulation (PMC) for the treatment of small solitary breast cancers. Materials and Methods: With approval of the institutional ethics committee and written informed consent, 41 patients with core-needlebiopsy-proved breast cancers 3.0 cm or less in diameter accessed by using ultrasonography (US) were recruited. US-guided PMC was performed with general anesthesia, followed immediately by mastectomy. Histochemical staining with α-nicotinamide adenine dinucleotide, reduced (NADH)-diaphorase was used to determine cell viability and the extent of PMC lesions. Results: The mean tumor volume was 5.26 cm ± 3.80 (standard deviation), with a range from 0.09 to 14.14 cm . PMC was successfully performed in all cases, with complete tumor ablation as assessed by using US. The mean time to reach complete ablation was 4.48 minutes, ranging from 3 to 10 minutes. With microscopic examination, 37 of 41 cases (90%; 95% confidence interval [CI]: 76.9%, 97.3%) showed complete tumor coagulation, as observed by using α-NADH-diaphorase staining. Of 38 cases diagnosed with invasive ductal carcinoma, 36 cases (95%; 95% CI: 82.3%, 99.4%) showed complete tumor coagulation. Slight thermal injuries to the skin and pectoralis major muscle, which proved reversible, were found in three cases. Conclusion: US-guided PMC of small solitary breast cancers is feasible. Nevertheless, larger-scale clinical trials are still needed to validate PMC for adoption into a standard clinical practice. © RSNA, 2012. 3 3
  • Authors

    Published In

  • Radiology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Zhou W; Zha X; Liu X; Ding Q; Chen L; Ni Y; Zhang Y; Xu Y; Chen L; Zhao Y
  • Start Page

  • 364
  • End Page

  • 373
  • Volume

  • 263
  • Issue

  • 2