Inhibition of CD4+ T cell function by the HIV envelope protein, gp120

Academic Article

Abstract

  • The CD4 molecule is functionally involved in the class II MHC-restricted T cell response to Ag. CD4 is also the receptor for HIV-1, the major etiologic agent of AIDS. We have assessed whether the interaction of the HIV-1 envelope protein with the CD4 molecule might interfere with the normal function of CD4, thereby contributing to the immunosuppression observed after HIV infection. Using a murine T cell hybridoma which expresses the human CD4 protein and exhibits a CD4-dependent response to Ag, we demonstrate that the HIV envelope protein gp120 can specifically inhibit this response.
  • Authors

    Published In

    Author List

  • Diamond DC; Sleckman BP; Gregory T; Lasky LA; Greenstein JL; Burakoff SJ
  • Start Page

  • 3715
  • End Page

  • 3717
  • Volume

  • 141
  • Issue

  • 11