Distinct effects of T-bet in Th1 lineage commitment and IFN-γ production in CD4 and CD8 T cells

Academic Article

Abstract

  • T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (T ) lymphocytes in part by activating the hallmark T 1 cytokine, interferon-γ (IFN-γ). IFN-γ is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-γ production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-γ is controlled by distinct transcriptional mechanisms within the T cell lineage. H H
  • Authors

    Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Szabo SJ; Sullivan BM; Sternmann C; Satoskar AR; Sleckman BP; Glimcher LH
  • Start Page

  • 338
  • End Page

  • 342
  • Volume

  • 295
  • Issue

  • 5553