T cell costimulation through CD28 depends on induction of the Bcl-xγ isoform: Analysis of Bcl-xγ-deficient mice

Academic Article

Abstract

  • The molecular basis of CD28-dependent costimulation of T cells is poorly understood. Bcl-xγ is a member of the Bcl-x family whose expression is restricted to activated T cells and requires CD28-dependent ligation for full expression. We report that Bcl-xγ-deficient (Bcl-xγ-/-) T cells display defective proliferative and cytokine responses to CD28-dependent costimulatory signals, impaired memory responses to proteolipid protein peptide (PLP), and do not develop PLP-induced experimental autoimmune encephalomyelitis (EAE). In contrast, enforced expression of Bcl-xγ largely replaces the requirement for B7-dependent ligation of CD28. These findings identify the Bcl-xγ cytosolic protein as an essential downstream link in the CD28-dependent signaling pathway that underlies T cell costimulation.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Ye Q; Press B; Kissler S; Yang XF; Lu L; Bassing CH; Sleckman BP; Jansson M; Panoutsakopoulou V; Trimble LA
  • Start Page

  • 87
  • End Page

  • 95
  • Volume

  • 196
  • Issue

  • 1