Collateral Damage from Antigen Receptor Gene Diversification

Academic Article

Abstract

  • Chromosomal translocations that juxtapose antigen receptor genes and oncogenes are frequently associated with lymphoid malignancies. In this issue, Robbiani et al. (2008) show that activation-induced deaminase (AID), an enzyme involved in antigen receptor gene diversification, generates DNA double-strand breaks (DSBs) in oncogenes, and Tsai et al. (2008) propose that AID and the recombinase-activating gene (RAG) endonuclease may collaborate to generate off-target DSBs. © 2008 Elsevier Inc. All rights reserved.
  • Authors

    Published In

  • Cell  Journal
  • Digital Object Identifier (doi)

    Author List

  • Mahowald GK; Baron JM; Sleckman BP
  • Start Page

  • 1009
  • End Page

  • 1012
  • Volume

  • 135
  • Issue

  • 6