Cutting Edge: Cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells

Academic Article

Abstract

  • During early stages of B-lineage differentiation in bone marrow, signals emanating from IL-7R and pre-BCR are thought to synergistically induce proliferative expansion of progenitor cells. Paradoxically, loss of pre- BCR-signaling components is associated with leukemia in both mice and humans. Exactly how progenitor B cells perform the task of balancing proliferative burst dependent on IL-7 with the termination of IL-7 signals and the initiation of L chain gene rearrangement remains to be elucidated. In this article, we provide genetic and functional evidence that the cessation of the IL-7 response of pre-B cells is controlled via a cellautonomous mechanism that operates at a discrete developmental transition inside Fraction C9 (large pre- BII) marked by transient expression of c-Myc. Our data indicate that pre-BCR cooperates with IL-7R in expanding the pre-B cell pool, but it is also critical to control the differentiation program shutting off the c-Myc gene in large pre-B cells. © 2013 by The American Association of Immunologists, Inc.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Sandoval GJ; Graham DB; Bhattacharya D; Sleckman BP; Xavier RJ; Swat W
  • Start Page

  • 2485
  • End Page

  • 2489
  • Volume

  • 190
  • Issue

  • 6