Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit

Academic Article

Abstract

  • © 2019 The British Infection Association Objective: Viral fitness plays an important role in HIV-1 evolution, transmission and pathogenesis. However, how mutations accumulated during early infection affect viral fitness has not been well studied. Methods: Paired infectious molecular clones (IMCs) for transmitted/founder (T/F) and 6-month (6-mo) viruses post infection were generated from 10 infected individuals to investigate the impact of accumulated mutations on viral fitness by comparing 6-mo viruses to their cognate T/F viruses. Results: All ten 6-mo viruses were less fit than their cognate T/F viruses. Moreover, the fitness losses of the 6-mo viruses correlated with the decrease in viral loads from the peak of viremia. Conclusion: These results show that the mutations accumulated during half a year post infection collectively reduce viral fitness and thereby contribute to lowering viral loads.
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    Author List

  • Wang C; Liu D; Zuo T; Hora B; Cai F; Ding H; Kappes J; Ochsenbauer C; Kong W; Yu X
  • Start Page

  • 210
  • End Page

  • 218
  • Volume

  • 80
  • Issue

  • 2