Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Academic Article

Abstract

  • Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function. © 2011 by American Society for Reproductive Medicine.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Ewens KG; Jones MR; Ankener W; Stewart DR; Urbanek M; Dunaif A; Legro RS; Chua A; Azziz R; Spielman RS
  • Volume

  • 95
  • Issue

  • 8