Epidemiology: Transmission of equine influenza virus to dogs

Academic Article


  • Molecular and antigenic analyses of three influenza viruses isolated from outbreaks of severe respiratory disease in racing greyhounds revealed that they are closely related to H3N8 equine influenza virus. Phylogenetic analysis indicated that the canine influenza virus genomes form a monophyletic group, consistent with a single interspecies virus transfer. Molecular changes in the hemagglutinin suggested adaptive evolution in the new host. The etiologic rote of this virus in respiratory disease was supported by the temporal association of rising antibody titers with disease and by experimental inoculation studies. The geographic expansion of the infection and its persistence for several years indicate efficient transmission of canine influenza virus among greyhounds. Evidence of infection in pet dogs suggests that this infection may also become enzootic in this population.
  • Authors

    Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Crawford PC; Dubovi EJ; Castleman WL; Stephenson I; Gibbs EPJ; Chen L; Smith C; Hill RC; Ferro P; Pompey J
  • Start Page

  • 482
  • End Page

  • 485
  • Volume

  • 310
  • Issue

  • 5747