Uterine angiosarcoma: A case report and literature review

Academic Article


  • Uterine angiosarcoma is a rare, extremely malignant vascular tumor. Here, we report a case of giant uterine angiosarcoma in a 56-yr-old woman. The tumor was diagnosed as an epithelioid uterine angiosarcoma based on histopathologic findings. The tumor cells showed vascular differentiation; they were positive for the vascular endothelial markers CD31, CD34, and was negative for lymphatic endothelial marker D2-40. In addition, the tumor cells showed overexpression of cell-cycle regulatory protein cyclin D1 and were positive for epithelial-mesenchymal transition marker vimentin. Although it was reported previously that there was breakage in YWHAE, NUTM2A (FAM22A), and NUTM2B (FAM22B) in a case of uterine angiosarcoma, no breakage in these loci was detected by fluorescence in situ hybridization in the present case.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Liu Y; Guo S; Wang L; Suzuki S; Sugimura H; Li Y
  • Start Page

  • 264
  • End Page

  • 268
  • Volume

  • 35
  • Issue

  • 3