Williams syndrome transcription factor is a target of pro-oncogenic Ser158 phosphorylation mediated by Ras-MAPK pathway in human breast cancer

Academic Article


  • Background: Williams Syndrome transcription factor (WSTF) has been implicated in a variety of cellular events. However, the roles of WSTF in human tumorigenesis have not been elucidated. Methods: The molecular and cellular assays were used to identify whether WSTF in MCF-7 cells is a downstream target of Ras-mitogen-activated protein kinase (MAPK) signaling pathway. Results: Ser158 of WSTF was phosphorylated following activation of MAPK signal, suggesting that WSTF may be a downstream target of MAPK signaling pathway. Conclusions: WSTFSer158 (WSTFS158) phosphorylation by Ras-MAPK contributes to tumorigenesis.
  • Authors

    Author List

  • Wang Y; Liu Y; Li Y; Zhang J; Liu Y; Li Y; Deng Y; Wang S
  • Start Page

  • 1668
  • End Page

  • 1675
  • Volume

  • 9
  • Issue

  • 2