Vaccine Adjuvants Derivatized from Momordica Saponins i and II

Academic Article

Abstract

  • We have derivatized Momordica saponins (MS) I and II through their coupling at C3 glucuronic acid site with dodecylamine. The derivatives show significantly different immunostimulant activity profiles from their respective natural parent saponins. In particular, adjuvant VSA-1 (5), the derivative of MS I, potentiates a significantly higher IgG2a responose than the corresponding natural product. Its IgG1 and IgG2a production is similar to that of GPI-0100, indicating a potential mixed and antigen-specific Th1/Th2 immune response, which is different from the Th2 immunity induced by the natural saponin MS I. In addition, toxicity evaluations show that adjuvant VSA-1 (5) is much less toxic than the widely used natural saponin mixture Quil A. These results prove that derivatizing Momordica saponins can be a viable way for easy access to structurally defined saponin immunostimulants with favorable adjvuant activity and low toxicity.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Wang P; Ding X; Kim H; ┼ákalamera ├ä; Michalek SM; Zhang P
  • Start Page

  • 9976
  • End Page

  • 9982
  • Volume

  • 62
  • Issue

  • 21