Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450,: B 5, and reductase

Academic Article

Abstract

  • Cytochrome P450 (cytP450) interacts with two redox partners, cytP450 reductase and cytochrome-b5, to metabolize substrates. Using NMR, we reveal changes in the dynamic interplay when all three proteins are incorporated into lipid nanodiscs in the absence and presence of substrates.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Gentry KA; Anantharamaiah GM; Ramamoorthy A
  • Start Page

  • 13422
  • End Page

  • 13425
  • Volume

  • 55
  • Issue

  • 89