Individualized recovery of gut microbial strains post antibiotics

Academic Article


  • © 2019, The Author(s). To further understand the impact of antibiotics on the gastrointestinal tract microbial community, the intra-individual recovery pattern of specific microbial strains was determined using metagenomic sequencing coupled with strain-tracking analyses. In a study where 18 individuals were administered a single antibiotic (cefprozil), new microbial genomic variants (herein strains) were transiently detected in 15 individuals, while in a second study that used a cocktail of three antibiotics (meropenem, gentamicin, and vancomycin), all 12 participants had either permanent or transient strain changes. The presence of distinct microbial genomic variants indicates a pattern of strain recovery that is intra-individual specific following disruption of the human gastrointestinal tract with antibiotics.
  • Digital Object Identifier (doi)

    Author List

  • Koo H; Hakim JA; Crossman DK; Kumar R; Lefkowitz EJ; Morrow CD
  • Volume

  • 5
  • Issue

  • 1