Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells.

Academic Article

Abstract

  • The earliest genetic alteration in human astrocytoma progression is mutation of the p53 tumour suppressor gene, while one of the earliest phenotypic changes is the stimulation of neovascularization. Here, we tested the role of p53 in the angiogenic process by introducing a tetracycline-regulated wild type p53 gene into null glioblastoma cells. The parental cells expressed strong angiogenic activity while upon induction of wild type, but not mutant, p53 expression, the cells secreted a factor able to neutralize the angiogenicity of the factors produced by the parental cells as well as of basic fibroblast growth factor.

    • Authors

    Published In

  • Nature Genetics  Journal

    • Keywords

  • Angiogenesis Inhibitors, Animals, Brain Neoplasms, Cell Movement, Cornea, Disease Progression, Endothelium, Vascular, Female, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Neoplasm Proteins, Neovascularization, Pathologic, Protein Biosynthesis, Proteins, Rats, Rats, Inbred F344, Tumor Cells, Cultured, Tumor Suppressor Protein p53

    • Digital Object Identifier (doi)

    Author List

  • Van Meir EG; Polverini PJ; Chazin VR; Su Huang HJ; de Tribolet N; Cavenee WK

    • Start Page

  • 171

    • End Page

  • 176

    • Volume

  • 8

    • Issue

  • 2