Purpose: The aim of this study was to determine the relative contribution of changes in implant system, position, bone type, and loading condition on the biomechanical response of a single-unit implant-supported restoration using nonlinear 3-dimensional finite element analysis (3D FEA). Materials and Methods: FEA models of a single-unit (crown) restoration supported by the Frialit-2 implant and MH-6 abutment or the Straumann standard implant with the Straumann solid abutment were used. Each system was analyzed by FEA with both straight and 20-degree angled abutments. Simulated implant placement was performed in the maxillary premolar area with 3 variations in implant orientation relative to the residual ridge. Analysis of each orientation was conducted for each of 4 bone quality types described by Lekholm and Zarb, with lateral and axial loading conditions imposed. The effect of each variable was expressed as a percentage of the total sum of squares as computed using analysis of variance. Results: Larger strain values were noted in cortical bone with lateral force and the Frialit-2 system. Bone strain increased with decreasing bone density and was affected primarily by bone quality. Implant stress was influenced mainly by implant position. Conclusions: Better stress/strain distribution is possible when implants are placed along the axis of loading with multiple areas of cortical contact. The Straumann solid abutment performed better as a force-transmission mechanism.