Trip6 regulates p27KIP1 to promote tumorigenesis

Academic Article

Abstract

  • TRIP6 is an adaptor protein that regulates cell motility and antiapoptotic signaling. Although it has been implicated in tumorigenesis, the underlying mechanism remains largely unknown. Here we provide evidence that TRIP6 promotes tumorigenesis by serving as a bridge to promote the recruitment of p27 to AKT in the cytosol. TRIP6 regulates the membrane translocation and activation of AKT and facilitates AKT-mediated recognition and phosphorylation of p27 specifically at T157, thereby promoting the cytosolic mislocalization of p27 . This is required for p27 to enhance lysophosphatidic acid (LPA)-induced ovarian cancer cell migration. TRIP6 also promotes serum-induced reduction of nuclear p27 expression levels through Skp2- dependent and -independent mechanisms. Consequently, knockdown of TRIP6 in glioblastoma or ovarian cancer xenografts restores nuclear p27 expression and impairs tumor proliferation. As TRIP6 is upregulated in gliomas and its levels correlate with poor clinical outcomes in a dose-dependent manner, it may represent a novel prognostic marker and therapeutic target in gliomas. © 2013, American Society for Microbiology. KIP1 KIP1 KIP1 KIP1 KIP1 KIP1
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Lin VTG; Lin VY; Lai YJ; Chen CS; Liu K; Lin WC; Lin FT
  • Start Page

  • 1394
  • End Page

  • 1409
  • Volume

  • 33
  • Issue

  • 7