Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma

Academic Article


  • Background: Pathologic extranodal extension (ENE) has traditionally guided the management of head and neck cancers. The prognostic value of radiographic ENE (rENE) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPX) is uncertain. Methods: Patients with HPV + OPX with adequate pretreatment radiographic nodal evaluation from a single institution were analyzed. rENE status was determined by neuroradiologists' at time of diagnosis. Distant metastasis-free survival (DMFS), overall survival (OS), and locoregional recurrence-free survival (LRFS) were estimated using Kaplan-Meier methods. Cox proportional hazards models were fit to assess the impact of rENE on survival endpoints. Results: Hundred sixty-eight patients with OPX + squamous cell carcinomas diagnosed between April 2008 and December 2014 were included for analysis with median follow-up of 3.3 years. Eighty-eight percent of patients received concurrent chemoradiotherapy. rENE was not prognostic; its presence in patients with HPV + OPX did not significantly impact OS, LRFS, or DMFS. Conclusions: In patients with HPV + OPX, rENE was not significantly associated with OS, LRFS, or DMFS.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Tian S; Ferris MJ; Switchenko JM; Magliocca KR; Cassidy RJ; Jhaveri J; Aiken AH; Baugnon KL; Hudgins PA; Kendi ATK
  • Start Page

  • 3056
  • End Page

  • 3063
  • Volume

  • 41
  • Issue

  • 9