© 2005 by Taylor & Francis Group, LLC. Diabetic nephropathy (DN) is a significant complication of diabetes mellitus (DM). Unfortunately, the incidence and prevalence of DM has risen. In 1994, there were 120 million diabetics worldwide. By 2010, there will be upwards of 240 million diabetics (1). Diabetic Nephropathy is a leading cause of end-stage renal disease (ESRD) in Western societies. In American and European adults, diabetics constitute more than 33 percent of all patients entering renal support programs (2, 3). Of these, 50 percent to 60 percent with DN have type 2 DM.