Determinants of HIV drug resistance mutations in plasma virus after treatment interruption

Academic Article

Abstract

  • This study examines the utility of resistance testing during treatment interruption, making comparisons with the current IAS guidelines. A total of 188/ 1279 tests (14%) were performed during treatment interruption; 69/188 tests (36.7%) demonstrated key mutations. Time off therapy and the total number of previous drugs were both significantly associated with the presence of mutations. We conclude that resistance testing is of value up to 3 months after treatment interrupsion, and may convey some benefit up to 12 months.
  • Authors

    Published In

  • AIDS  Journal
  • Digital Object Identifier (doi)

    Author List

  • Chilton D; Dervisevic S; Pillay D; Rider A; Copas A; Miller RF; Edwards SG
  • Start Page

  • 2174
  • End Page

  • 2175
  • Volume

  • 19
  • Issue

  • 18