AIDS and the lung

Academic Article


  • Respiratory problems continue to be a major burden of disease in HIV-infected patients, with more than 50% suffering at least one respiratory episode. In early HIV infection, respiratory infections are similar to those found in the general population, but more common. Progressive HIV-induced immunosuppression increases the risk of opportunistic infections and tumours. Highly active antiretroviral therapy (HAART) has reduced the incidence of HIV-associated opportunistic infections and tumours, but has had less impact on the incidence of bacterial pneumonia, tuberculosis and non-Hodgkin lymphoma. HAART may trigger immune phenomena including over-exuberant and uncontrolled immune response to exogenous antigen most commonly seen in Mycobacterium tuberculosis, where two 'syndromes' have been described: immune reconstitution inflammatory syndrome (IRIS) and 'unmasking' of asymptomatic, latent, indolent or incipient infection (ALI3). © 2009 Elsevier Ltd. All rights reserved.
  • Authors

    Published In

  • Medicine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Sage B; Miller R
  • Start Page

  • 342
  • End Page

  • 347
  • Volume

  • 37
  • Issue

  • 7