Diagnostic utility of fine needle aspiration (FNA) cytology in HIV- infected patients with lymphadenopathy

Academic Article

Abstract

  • Sixty-five FNA cytology procedures were performed on lymph nodes in 52 HIV+ patients. Cervical lymph nodes were the commonest site of FNA cytology investigation (54%). The diagnoses were persistent generalized lymphadenopathy (38%), infection (17%), and malignancy (11%). Diagnosis could not be rendered in 25% of FNA cytology due to inadequate sampling. Of those with infection, mycobacterial disease was the commonest cause (91%), the diagnosis of which was enhanced by concurrent microbiological examination. Non-Hodgkin's lymphoma was the commonest malignancy. Sixteen lymph node FNA cytologies had subsequent tissue biopsy. There were two false-positive and four false-negative FNA cytologies. FNA cytology in HIV+ patients is most useful in the diagnosis of infection, obviating the need for tissue biopsy and allowing prompt initiation of treatment.
  • Authors

    Published In

  • Cytopathology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Reid AJC; Miller RF; Kocjan GI
  • Start Page

  • 230
  • End Page

  • 239
  • Volume

  • 9
  • Issue

  • 4