Analysis of Genetic Diversity at the arom Locus in Isolates of Pneumocystis carinii

Academic Article

Abstract

  • ABSTRACT. The DNA sequences of a portion of the 5‐enolpyruvyl shikimate phosphate synthase domain of the arom gene, encoding the pentafunctional AROM protein, were determined from isolates of Pneumocystis carinii from five mammalian host species (rat, human, ferret, rabbit and mouse). High levels of genetic divergence were found among P. carinii derived from different hosts species, 7–22% at the DNA sequence level, and 7–26% at the derived amino acid sequence level. Two separate and distinct sequences were isolated from infected ferret lungs. Low levels of divergence were seen in human‐derived organisms. Copyright © 1995, Wiley Blackwell. All rights reserved
  • Authors

    Digital Object Identifier (doi)

    Author List

  • BANERJI S; LUGLI EB; MILLER RF; WAKEFIELD AE
  • Start Page

  • 675
  • End Page

  • 679
  • Volume

  • 42
  • Issue

  • 6