Thrombotic thrombocytopaenic purpura in HIV-infected patients

Academic Article


  • Thrombotic thrombocytopaenic purpura (TTP) results from deficiency of von Willebrand factor-cleaving protease (vWF-cp) activity. Eight HIV-infected patients presented with TTP, representing 12.5% of all TTP treated at this centre. In four patients presentation with TTP revealed underlying HIV infection, the other four patients were previously known to be HIV infected, with plasma exchange and highly active antiretroviral therapy (HAART) all recovered. Normalization of vWF-cp activity was associated with recovery. Relapse occurred in two patients who discontinued HAART against medical advice, suggesting that HIV has a causal role in this condition. Given the clear benefit from HAART in addition to plasma exchange, these data suggest that all patients presenting with TTP should undergo HIV testing.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Miller RF; Scully M; Cohen H; Roedling S; Starke R; Edwards SG; Machin SJ
  • Start Page

  • 538
  • End Page

  • 542
  • Volume

  • 16
  • Issue

  • 8