Cystic hypersecretory carcinoma of the breast with Paget disease of the nipple: A diagnostic challenge

Academic Article


  • A unique case of cystic hypersecretory carcinoma in a 48-year-old woman who presented with a tender, palpable abnormality of the lower outer quadrant of her left breast in 2002 is described. Mammographic and ultrasound examinations showed heterogeneous, dense breast tissue with a focal asymmetric density and an ill-defined heterogenous hypoechoic area with anechoic spaces, respectively, that corresponded to the area of palpable abnormality. Although the imaging findings did not change significantly over 4 years, the patient complained of intermittent, spontaneous serous discharge from the left nipple and persistent induration and tenderness in the same area of the left breast. An ultrasound-guided core-needle biopsy of the lesion was performed at the last visit to rule out a malignant process. A left simple mastectomy showed a large multicystic lesion occupying most of the lower quadrants by a cystic hypersecretory carcinoma and Paget disease of the nipple. © 2008 Sage Publications.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Sahoo S; Gopal P; Roland L; Pile N
  • Start Page

  • 208
  • End Page

  • 212
  • Volume

  • 16
  • Issue

  • 2