Topiramate increases cerebral GABA in healthy humans

Academic Article


  • Topiramate (TOP) is a novel anticonvulsant drug with multiple mechanisms of action used in the treatment of epilepsy. Measurements of cerebral GABA were obtained in six controls using 1H MRS at baseline and at 3 and 6 hours following the administration of 3 mg/kg of TOP. Brain GABA concentrations rose by 72% at 3 hours and by 64% at 6 hours compared with baseline (p < 0.004). This study demonstrates that TOP significantly increases human cerebral GABA concentrations in healthy individuals.
  • Authors

    Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 26073737
  • Author List

  • Kuzniecky R; Hetherington H; Ho S; Pan J; Martin R; Gilliam F; Hugg J; Faught E
  • Start Page

  • 627
  • End Page

  • 629
  • Volume

  • 51
  • Issue

  • 2