Probing membrane enhanced protein-protein interactions in a minimal redox complex of cytochrome-P450 and P450-reductase

Academic Article

Abstract

  • Investigating the interplay in a minimal redox complex of cytochrome-P450 and its reductase is crucial for understanding cytochrome-P450's enzymatic activity. Probing the hotspots of dynamic structural interactions using NMR revealed the engagement of loop residues from P450-reductase to be responsible for the enhanced affinity of CYP450 towards its obligate redox partner.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Mahajan M; Ravula T; Prade E; Anantharamaiah GM; Ramamoorthy A
  • Start Page

  • 5777
  • End Page

  • 5780
  • Volume

  • 55
  • Issue

  • 41