Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents

Academic Article

Abstract

  • Neovascularization characterizes diabetic retinopathy and choroidal neovascularization associated with age-related macular degeneration, the most common causes of severe visual loss in the developed world. Gene transfer to the eye using adeno-associated viral (AAV) vectors is a promising new treatment for inherited and acquired ocular diseases. We used an AAV vector with rapid onset and high levels of gene expression in the retina to deliver three anti-angiogenic factors (pigment epithelium-derived factor, tissue inhibitor of metalloproteinase-3, and endostatin) to the eyes of mice in a mouse model of retinopathy of prematurity. All three vectors inhibited ischemia-induced neovascularization.
  • Authors

    Published In

  • Molecular Therapy  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 3662982
  • Author List

  • Auricchio A; Behling KC; Maguire AM; O'Connor EE; Bennett J; Wilson JM; Tolentino MJ
  • Start Page

  • 490
  • End Page

  • 494
  • Volume

  • 6
  • Issue

  • 4