High-resolution adaptive optics retinal imaging of cellular structure in choroideremia

Academic Article


  • RESULTS: The SLO imaging revealed scalloped edges of RPE atrophy and large choroidal vessels. The AF imaging showed hypo-AF in areas of degeneration, while central AF remained present. OCT images showed outer retinal tubulations and thinned RPE/interdigitation layers. The AOSLO imaging revealed the cone mosaic in central relatively intact retina, and cone density was either reduced or normal at 0.5 mm eccentricity. The border of RPE atrophy showed abrupt loss of the cone mosaic at the same location. The AF imaging in comparison with AOSLO showed RPE health may be compromised before cone degeneration. Other disease features, including visualization of choroidal vessels, hyper-reflective clumps of cones, and unique retinal findings, were tabulated to show the frequency of occurrence and model disease progression.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Morgan JIW; Han G; Klinman E; Maguire WM; Chung DC; Maguire AM; Bennett J
  • Start Page

  • 6381
  • End Page

  • 6397
  • Volume

  • 55
  • Issue

  • 10