Total Synthesis of Avermectin B1a: Synthesis of the Carbohydrate Bis-Oleandrose Fragment and Coupling to the Avermectin B1a Aglycone

Academic Article


  • © 1990 Georg Thieme Verlag. All rights reserved. A synthesis of the bis-oleandrose fragment of avermectin B1a (1) is described, involving π-allyl tricarbonyliron lactone complexes as key synthetic intermediates. Final glycosidation to the aglycone employed the use of an imidazolylthiocarbonyl glycoside, to conclude the total synthesis of avermectin B1a.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Ford MJ; Knight JG; Ley SV; Vile S
  • Start Page

  • 331
  • End Page

  • 332
  • Volume

  • 1990
  • Issue

  • 6