Computational modeling of transport processes in a bioreactor for the production of engineered cartilage

Academic Article


  • The goal of this study was to model the hydrodynamic environment of a concentric cylinder viscometer used to grow tissue-engineered cartilage. FLUENT CFD models were developed to determine operating conditions to optimize cartilage production by quantifying shear stresses, flow fields, and mass transfer characteristics around constructs in the bioreactor. The 3-D models show a maximum shear stress of 5 dyn/cm2 around the construct leading edge, a decaying stress distribution across the construct face, and low velocity recirculation/redevelopment regions after the constructs. Maximum shear stress and stress distribution (1.5-5 dyn/cm2) on the construct face vary with the number and relative position of bioreactor constructs.
  • Volume

  • 28