Frontal hypermetabolism and thalamic hypometabolism in a patient with abnormal orienting and retrosplenial amnesia

Academic Article


  • A patient with verbal amnesia and a propensity to direct his attention to the right following a retrosplenial area lesion was studied with positron emission tomography using [F-18] fluorodeoxyglucose. These studies showed that the left thalamus was hypometabolic, and the anterior 2/3 of the left hemisphere was hypermetabolic when compared with the right. There were no significant differences seen in the medial temporal lobes. Based on this study, it is posited that interruption of hippocampal input into the anterior thalamus was responsible for the amnesia, and the left frontal hyperactivity was associated with the propensity to attend contralaterally. © 1990.
  • Authors

    Published In

  • Neuropsychologia  Journal
  • Digital Object Identifier (doi)

    Author List

  • Heilman KM; Bowers D; Watson RT; Day A; Valenstein E; Hammond E; Duara R
  • Start Page

  • 161
  • End Page

  • 169
  • Volume

  • 28
  • Issue

  • 2